Ursin reduce neuronal loss and astrocytes activation in chemical kindling model of epilepsy
نویسندگان
چکیده
منابع مشابه
Myristica fragrans Houtt extract attenuates neuronal loss and glial activation in pentylenetetrazol-induced kindling model
Inflammatory reactions are closely associated with the development and progression of epilepsy. It has been shown that inhibition of pro-inflammatory cytokines, which are released from activated astrocytes and microglia, are considered to be an effective therapeutic approach for the treatment of epileptic disorders. Regarding the anti-inflammatory effects of nutmeg (Myristica fragrans Houtt), t...
متن کاملMyristica fragrans Houtt extract attenuates neuronal loss and glial activation in pentylenetetrazol-induced kindling model
Inflammatory reactions are closely associated with the development and progression of epilepsy. It has been shown that inhibition of pro-inflammatory cytokines, which are released from activated astrocytes and microglia, are considered to be an effective therapeutic approach for the treatment of epileptic disorders. Regarding the anti-inflammatory effects of nutmeg (Myristica fragrans Houtt), t...
متن کاملZingiber officinale extract pre-treatment ameliorates astrocytes activation and enhances neuroprotection in pentylenetetrazol-induced kindling model of epilepsy in mice
Introduction: Recently, herbal medicine is widely used as an alternative and complementary therapy in several neurological disorders such as epilepsy. The anti-inflammatory and neuroprotective effects of Zingiber officinale or ginger have been well-documented. The present study was designed to evaluate the effects of ginger extract pre-treatment on seizures behavior, neuronal density and as...
متن کاملA Review on Chemical Induced Kindling Models of Epilepsy
A variety of animal models have been developed to study the effect of antiepileptic drugs. These models provide the means of inducing changes and causing alterations in neural function which may lead to epileptogenesis. Kindling is a lasting change in brain function caused by repeated stimulation resulting an increased seizure duration and progressive intensification of seizure activity. The ki...
متن کاملPiracetam prevents pentylenetetrazol kindling-induced neuronal loss and learning deficits
The effect of the nootropic drug piracetam (100 mg/kg) on kindled seizures, kindling-induced learning deficits, and histological alterations due to changes in central excitability was investigated in Wistar rats. The animals were kindled by repeated i.p. injections of an initially subconvulsive dose of pentylenetetrazol (PTZ). As a control, piracetam or physiological saline was given 60 minutes...
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ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.1574